Literature evidence must open to a source
Cite only returned PMID/DOI records; zero hits do not establish novelty.
Related methods: LITERATUREGAP
Rules
- Search PubMed and OpenAlex.
- Mechanistic claims require an openable link.
- Preserve queries, filters, and hit counts by source.
Research gaps
A candidate gap must show support, counterevidence, uncertainty, and feasibility. “No result” cannot become “never studied.”