Experimental design, protocol review, and follow-up
Controls, replicates, batches, and validation must map to an observed data gap.
Related methods: DESIGNFOLLOWUPPROTOCOL
Design
State the model or population, control, biological replicates, primary endpoint, and statistical plan. Observational designs do not support causal upgrades.
Follow-up
Recommendations must arise from observed gaps such as n<3, missing batch information, no significant result, or absent orthogonal validation.